By Leo Sachs (auth.), Prof. Dr. W. Hiddemann, Priv.-Doz. Dr. W. Plunkett, Prof. Dr. T. Büchner, Prof. Dr. J. Ritter, B. Wörmann M.D., Ph.D., M. J. Keating M.D., B.S., Prof. Dr. U. Creutzig (eds.)
This quantity, the 5th in a chain on acute leukemias, focuses quite on contemporary uncomplicated study effects and novel healing ways to the affliction. features of leukemia cellphone biology, together with differentiation, the mechanisms of drug resistance, the pharmacology of cytostatic brokers and the result of scientific trials in relapsed and refractory disorder are lined through striking foreign specialists within the respective fields. destiny advancements together with new brokers and new cures reminiscent of unrelated bone marrow transplantation, immunotargeting and gene treatment entire a cutting-edge summery of present wisdom in experimental leukemia therapy.
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Extra info for Acute Leukemias V: Experimental Approaches and Management of Refractory Disease
20. , Sachs 1. 1971. Characterization of the inducer required for the development of macrophage and granulocyte colonies. Proc. Natl. Acad. Sei. USA 68: 2540-2544. 21. , Metcalf D. 1977. Purification and properties of colony-stimulating factor from mouse lung conditioned medium. J. Biol. Chem. 252: 1998-2003. 22. M. 1977. Factors regulating macrophage production and growth. Purification and some properties of the colony stimulating factor from medium conditioned by mouse cells. J. Biol. Chem. 252: 4305-4312.
Alternative pathways to regulate apoptosis can be useful to control selective cell viability. Treatments that downregulate the expression or activity of mutant P53 or bcl-2 in tumor cells should be useful for cancer therapy . Indeed, induction of differentiation by IL-6 or G-CSF downregulated bcl-2 expression and increased the susceptibility of the cells to induction of apoptosis [671. References 1. , Sachs L. 1963. Formation of pure suspensions of mast cells in tissue culture by differentiation of lymphoid cells from the mouse thymus.
Bio!. 101: 221-224. 46. Sachs L. 1987. Cell differentiation and by-passing of genetic defects in the suppression of malignancy. , 47: 1981-1986. 47. , Sachs, L. 1988. DNA rearrangement of ahorneobox gene in myeloid leukaemic cells. , 7: 4283-4290. 48. , Sachs, L. 1992. 4 homeobox gene. , 3: 671-676. 49. , Sachs, L. 1977. Chromosome mapping of the genes that control differentiation and malignancy in myeloid leukemic cells. Proc. Nat!. Acad. Sei. USA, 74: 253-257. 50. , Sachs, L. 1988. Deletion of ahorneobox gene in myeloid leukemias with a deletion in chromosome 2.