Antimutagenesis and Anticarcinogenesis Mechanisms II by Yukiaki Kuroda (auth.), Yukiaki Kuroda, Delbert M. Shankel,

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By Yukiaki Kuroda (auth.), Yukiaki Kuroda, Delbert M. Shankel, Michael D. Waters (eds.)

From e-book information, Inc.
The papers are prepared in 8 sections, addressing: antimutagens in nutrients; antimutagens and anticarcinogens in environmental toxicology; unfastened radicals; antitumor initiators; antitumor promoters; elements of mammalian and human genetics; molecular elements of mutagenesis and antimutageneis; and oncogenes and antioncogenes.
Annotation copyright booklet information, Inc. Portland, Or.

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In the cases of small-cell lung carcinoma examined, loss of heterozygosity was observed on chromosome 3p in all 7 cases, on 13q in 10 of 11 cases, and on 17p in all 5 cases examined (Tab. 7) (24). The 13q deletion was found to be in a range covering the RB (retinoblastoma) gene. Studies by Yokota's group at the National Cancer Center using a monoclonal antibody to a synthetic peptide of the carboxy-terminal region of the RB protein showed that this protein was always missing in small-cell lung carcinomas (27).

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Nutr. Metabol. 18:272-282. , T. Takata, M. Sakaguchi, H. Takada, M. Yamamura, K. Hioki, and M. Yamamoto (1988) Effect of dietary eicosapentaenoic acid on azoxymethane--induced colon carcinogenesis in rats. Cancer Res. 48:4790-4794. P. Hansen (1980) Breast cancer in Greenland-Selected epidemiological and historical features. J. Cancer Res. Clin. Oncol. 98:287-299. W. E. Boyd (1986) Inhibition of intestinal carcinogenesis in rats: Effect of difluoromethylornithine with piroxicam or fish oil. J. NaU.

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