Approaches to New Leads for Insecticides by U. Eder, H. C. von Keyserlingk (auth.), Dr. Harald C. von

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By U. Eder, H. C. von Keyserlingk (auth.), Dr. Harald C. von Keyserlingk, Dr. Albert Jäger, Dr. Christoph von Szczepanski (eds.)

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From Adams and Miller 1979) stead of the nice coordination, which you can see on the right of these four traces (Fig. 4), he was getting short bursts followed by pauses. Now we initially thought that these bursts were originating in the central nervous system because it was suggested by a group at Rothamsted Experimental Station that all pyrethroid actions were central and none were peripheral. Dr. 5) to determine the origin of the bursts. He recorded from two places along the axon connecting the central nervous system with one flight muscle and from the muscle itself.

A. Miller Table 3. Bioassay of sodium channel drugs on third instar larvae, Musca domestica by the thermal stimulus-response method. 0· • Dose giving 50% paralysis 10min after treatment b Tetrodotoxin values for ED so are in pg • Significant differences between strains fected by procaine or tetrodotoxin is not altered in this kdr strain. 6 ~g versus far greater than 10). Components of scorpion venom that are suspected to act on certain parts of the sodium channel show a similar bioassay response, so what the kdr gene has done to the sodium channel alters responses to deltamethrin and aconitine but it does not affect responses to procaine, tetrodotoxin, and scorpion venom.

J Comp Physiol 64:243-253 Omer SM, Georghiou GP, Irving SN (1980) DDT/pyrethroid resistance interrelationships in Anopheles stephensi. Mosquito News 40:200-209 Salgado VL, Irving SN, Miller TA (1983) Depolarization ofmotor nerve terminals by pyrethroids in susceptible and kdr-resistant house flies. Pestic Biochem Physiol 20: 100-114 Sparks TC, Shour MH, Wellemeyer EG (1982) Temperature-toxicity relationships of pyrethroids on three lepidopterans. J Econ Entomol 75:643-646 Usherwood PNR, Grundfest H (1965) Peripheral inhibition in skeletal muscle of insects.

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