By S. M. Fischer, T. J. Slaga (auth.), Susan M. Fischer, Thomas J. Slaga (eds.)
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Extra resources for Arachidonic Acid Metabolism and Tumor Promotion
The role of prostaglandins in epidermal cell proliferation in vivo ••• A. Epidermal cell proliferation in normal adult epidermis. B. Induction of epidermal hyperproliferation and hyperplasia in adult mouse skin C. Epidermal cell proliferation in neonatal mouse skin · 50 50 50 52 54 The role of prostaglandins in epidermal cell proliferation in vitro . • . • • • . • . • • 55 The role of prostaglandins in the process of tumor promotion • • . • • • • • • A. Two-stage tumor promotion in mouse skin B.
CONCLUSION The above studies indicate that while the prostaglandins or other metabolites of arachidonic acid metabolism that have been tested to date are not tumor promoters themselves, they play an integral part in the underlying mechanism of tumor promotion. The thromboxanes, prostacyclin and leukotrienes have not yet been investigated; information on the contribution of these to tumor promotion will be of value. Tumor promotion studies using the phorbol ester TPA in SENCAR mice have shown that (I) exogenous application of various prostaglandins can modify the tumor yield, the direction being dependent on the particular prostaglandin used, and (II) the lipoxygenase pathway of arachidonic acid metaboli sm is important if not essential to promotion.
Experiments were done twice, on different cell isolations. b5,8,ll,14 eicosatetraynoic acid cnordihydrogauiaretic acid dpreincubation used 42 v. CONCLUSION The above studies indicate that while the prostaglandins or other metabolites of arachidonic acid metabolism that have been tested to date are not tumor promoters themselves, they play an integral part in the underlying mechanism of tumor promotion. The thromboxanes, prostacyclin and leukotrienes have not yet been investigated; information on the contribution of these to tumor promotion will be of value.