Cardiac Drug Development Guide (Methods in Pharmacology and by Michael K. Pugsley

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By Michael K. Pugsley

Cardiac Drug improvement advisor outlines, intimately, the therapeutics of cardiac medication at the moment on the leading edge of clinical study and improvement all over the world. This quantity integrates uncomplicated and medical cardiac pharmacology by means of c- bining, for the 1st time, either classical and molecular features of healing drug improvement. The chapters contain a huge spectrum of healing parts and accordingly contain a entire dialogue of molecular, biochemical, and electrophy- ological options in response to years of in vitro in addition to in vivo pharmacological st- ies. additionally, the latter a part of the e-book contains entire medical cardiac chapters that describe very important issues in molecular medication. those chapters additionally speak about present medical healing tendencies in drugs and supply an assessment of the efficacy of novel medicines in those parts. Cardiac Drug improvement consultant has many distinct and notable good points that set it except different cardiac pharmacology books. This e-book introduces themes in an simply comprehensible layout for researchers in lots of various disciplines via integrating and thereby simplifying recommendations now not often mentioned throughout a vast variety of cardiac disciplines and in a hugely technical box. every one bankruptcy not just introduces and describes the body structure, pharmacology, and pathophysiology of the ailment, but in addition overviews the medical implications of drug improvement, what phases those components are at present in, and in addition stories many of the methodologies taken with drug discovery and improvement. for this reason, this publication offers a entire review of the main complicated tactics in cardiac pharmacology at the present time.

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And Tromba, C. (1988) Inhibition of the hyperpolarization-activated current (if) induced by acetylcholine in rabbit sino-atrial node myocytes. J. Physiol. 405, 477–491. 34. Santoro, B. and Tibbs, G. R. (1999) The HCN gene family: Molecular basis of the hyperpolarization-activated pacemaker channels. Ann. NY Acad. Sci. 868, 741–764. 35. , and Cohen, I. S. (1995) Pacemaker current If in adult canine cardiac ventricular myocytes. J. Physiol. 485, 469–483. 36. , Grant, S. , and Kandel, E. R. (1997) Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels.

Rosen, M. , and Tromba, C. (1991) Effects of protein kinase inhibitors on canine Purkinje fibre pacemaker depolarization and the pacemaker current i(f). J. Physiol. 440, 367–384. 30. Wu, J. , and Cohen, I. S. (2000) Epidermal growth factor increases i(f) in rabbit SA node cells by activating a tyrosine kinase. Biochim. Biophys. Acta. 1463, 1–19. 31. , and Bois, P. (2000) Thyroid hormone increases the conductance density of f-channels in rabbit sino-atrial node cells. Receptors Channels 7, 1–8.

And DiFrancesco, D. (1992) Reciprocal role of the inward currents ib, Na and i(f) in controlling and stabilizing pacemaker frequency of rabbit sino-atrial node cells. Proc. R Soc. Lond. B Biol. Sci. 250, 199–207. 22. Liu, Y. , Li, C. , Cohen, I. , and Vassalle, M. (1998) Cesium effects on If and IK in rabbit sinoatrial node myocytes. Implications for SA node automaticity. J. Cardiovasc. Pharmacol. 32, 783–790. 23. , Warren, K. , and Fishman, M. C. (1997) Defective “pacemaker” current (Ih) in a zebrafish mutant with a slow heart rate.

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